慢性骨髄性白血病を発症したp210BCR/ABLトランスジェニックマウスでは、顆粒増殖による脾臓の腫大(白三角)と顆粒球浸潤による腸管の肥厚(矢印)を認める。また、末梢血、骨髄、脾臓では分化傾向を有する顆粒球系の細胞の増殖を認める(上図左)。慢性骨髄性白血病の急性転化遺伝子として同定したZfp423について、p210BCR/ABL単独では慢性骨髄性白血病の病理像を認めるのに対し(上図右上)、p210BCR/ABLと共にZfp423を発現させると急性転化の病理像が認められた(上図右下)。

Publication 1
Overexpression/enhanced kinase activity of BCR/ABL and altered expression of Notch1 induced acute leukemia in p210BCR/ABL transgenic mice.
Oncogene. 2008 May 29;27(24):3465-74. doi: 10.1038/sj.onc.1211007.
Mizuno T, Yamasaki N, Miyazaki K, Tazaki T, Koller R, Oda H, Honda ZI, Ochi M, Wolff L, *Honda H.

Publication 2
Enhanced expression of p210BCR/ABL and aberrant expression of Zfp423/ZNF423 induce blast crisis of chronic myelogenous leukemia.
Blood. 2009 May 7;113(19):4702-10. doi: 10.1182/blood-2007-05-088724.
Miyazaki K, Yamasaki N, Oda H, Kuwata T, Kanno Y, Miyazaki M, Komeno Y, Kitaura J, Honda Z, Warming S, Jenkins NA, Copeland NG, Kitamura T, Nakamura T, *Honda H.

Publication 3
Haploinsufficiency and acquired loss of Bcl11b and H2AX induces blast crisis of chronic myelogenous leukemia in a transgenic mouse model.
Cancer Sci. 2009 Jul;100(7):1219-26. doi: 10.1111/j.1349-7006.2009.01172.x.
Nagamachi A, Yamasaki N, Miyazaki K, Oda H, Miyazaki M, Honda Z, Kominami R, Inaba T, *Honda H.

Publication 4
Crk-associated substrate lymphocyte type regulates myeloid cell motility and suppresses the progression of leukemia induced by p210Bcr/Abl.
Cancer Sci. 2011 Dec;102(12):2109-17. doi: 10.1111/j.1349-7006.2011.02066.x.
Seo S, Nakamoto T, Takeshita M, Lu J, Sato T, Suzuki T, Kamikubo Y, Ichikawa M, Noda M, Ogawa S, Honda H, Oda H, Kurokawa M. P

Publication 5
The IL-2/CD25 axis maintains distinct subsets of chronic myeloid leukemia-initiating cells.
Blood. 2014 Apr 17;123(16):2540-9. doi: 10.1182/blood-2013-07-517847.
Kobayashi CI, Takubo K, Kobayashi H, Nakamura-Ishizu A, Honda H, Kataoka K, Kumano K, Akiyama H, Sudo T, Kurokawa M, Suda T.