英文原著
2024
Somatic mutations in tumor-infiltrating lymphocytes impact on antitumor
immunity.
Proc Natl Acad Sci U S A. 2024 Aug 27;121(35):e2320189121. doi: 10.1073/pnas.2320189121. Epub 2024
Aug 21.
Mukohara F, Iwata K, Ishino T, Inozume T, Nagasaki J, Ueda Y, Suzawa K,
Ueno T, Ikeda H, Kawase K, Saeki Y, Kawashima S, Yamashita K, Kawahara
Y, Nakamura Y, Honobe-Tabuchi A, Watanabe H, Dansako H, Kawamura T, Suzuki
Y, Honda H, Mano H, Toyooka S, *Kawazu M, *Togashi Y.
PTIP epigenetically regulates DNA damage-induced cell cycle arrest by upregulating
PRDM1.
Sci Rep. 2024 Aug 3;14(1):17987. doi: 10.1038/s41598-024-68295-w.
*Nakata Y, Nagasawa S, Sera Y, Yamasaki N, Kanai A, Kobatake K, Ueda T, Koizumi M, Manabe I, Kaminuma O, *Honda H.
STING/RANTES pathway in airway epithelium enhances Der p1-induced airway
inflammation.
Allergy. 2024 Jul;79(7):2008-2011. doi: 10.1111/all.16173. Epub 2024 Jun 4.
*Tsuji M, *Kondo M, Nishiyama A, Tamura T, Nakamura-Ishizu A, Koizumi M, Honda H, Tagaya E.
Activation of NOTCH signaling impedes cell proliferation and survival in
acute megakaryoblastic leukemia.
Exp Hematol.2024 Jun 13;137:104255. doi: 10.1016/j.exphem.2024.104255. Epub ahead of
print.
Ong KOK, Mok MMH, Niibori-Nambu A, Du L, Yanagida M, Wang CQ, Bahirvani
AG, Chin DWL, Koh CP, Ng KP, Yamashita N, Jacob B, Yokomizo T, Takizawa
H, Matsumura T, Suda T, Lau JA, Tan TZ, Mori S, Yang H, Iwasaki M, Minami T, Asou N, Sun QY, Ding LW, Koeffler HP, Tenen DG, Shimizu R,
Yamamoto M, Ito Y, Kham SKY, *Yeoh AE, *Chng WJ, *Osato M.
Context-dependent modification of PFKFB3 in hematopoietic stem cells promotes
anaerobic glycolysis and ensures stress hematopoiesis.
Elife. 2024 Apr 4;12:RP87674. doi: 10.7554/eLife.87674.
Watanuki S, *Kobayashi H, Sugiura Y, Yamamoto M, Karigane D, Shiroshita
K, Sorimachi Y, Fujita S, Morikawa T, Koide S, Oshima M, Nishiyama A, Murakami
K, Haraguchi M, Tamaki S, Yamamoto T, Yabushita T, Tanaka Y, Nagamatsu
G, Honda H, Okamoto S, Goda N, Tamura T, Nakamura-Ishizu A, Suematsu M, Iwama A,
Suda T, *Takubo K.
Rev1 overexpression accelerates N-methyl-N-nitrosourea (MNU)-induced thymic
lymphoma by increasing mutagenesis.
Cancer Sci. 2024 Jun;115(6):1808-1819. doi: 10.1111/cas.16159. Epub 2024 Apr 4.
*Sasatani M, Xi Y, Daino K, Ishikawa A, Masuda Y, Kajimura J, Piao J, Zaharieva
EK, Honda H, Zhou G, Hamasaki K, Kusunoki Y, Shimura T, Kakinuma S, Shimada Y, Doi
K, Ishikawa-Fujiwara T, Sotomaru Y, *Kamiya K.
2023
Elevated stress response marks deeply quiescent reserve cells of gastric
chief cells.
Commun Biol. 2023 Nov 20;6(1):1183. doi: 10.1038/s42003-023-05550-2.
Shiokawa D, Sakai H, Koizumi M, Okimoto Y, Mori Y, Kanda Y, Ohata H, *Honda H, *Okamoto K.
UTX inactivation in germinal center B cells promotes the development of
multiple myeloma with extramedullary disease.
Leukemia.2023 Sep;37(9):1895-1907. doi: 10.1038/s41375-023-01928-7. Epub 2023 May
17.
Rizq O, *Mimura N, Oshima M, Momose S, Takayama N, Itokawa N, Koide S,
Shibamiya A, Miyamoto-Nagai Y, Rizk M, Nakajima-Takagi Y, Aoyama K, Wang
C, Saraya A, Ito R, Seimiya M, Watanabe M, Yamasaki S, Shibata T, Yamaguchi
K, Furukawa Y, Chiba T, Sakaida E, Nakaseko C, Tamaru JI, Tai YT, Anderson
KC, Honda H, *Iwama A.
The pathogenetic significance of exhausted T cells in a mouse model of
mature B cell neoplasms.
Cancer Immunol Immunother.2023 Aug;72(8):2635-2648. doi: 10.1007/s00262-023-03447-x.
Shibamiya A, Miyamoto-Nagai Y, Koide S, Oshima M, Rizq O, Aoyama K, Nakajima-Takagi
Y, Kato R, Kayamori K, Isshiki Y, Oshima-Hasegawa N, Muto T, Tsukamoto
S, Takeda Y, Koyama-Nasu R, Chiba T, Honda H, Yokote K, Iwama A, Sakaida E, *Mimura N.
MBTD1 preserves adult hematopoietic stem cell pool size and function.
Proc Natl Acad Sci U S A. 2023 Aug 8;120(32):e2206860120. doi: 10.1073/pnas.2206860120. Epub 2023
Jul 31.
*Takubo K, Htun PW, Ueda T, Sera Y, Iwasaki M, Koizumi M, Shiroshita K, Kobayashi H, Haraguchi M, Watanuki S, Honda ZI, Yamasaki
N, Nakamura-Ishizu A, Arai F, Motoyama N, Hatta T, Natsume T, Suda T, *Honda H.
Enhancer remodeling drives MLL oncogene-dependent transcriptional dysregulation
in leukemia stem cells.
Blood Adv.2023 Jun 13;7(11):2504-2519. doi: 10.1182/bloodadvances.2022008787.
Pan F, Iwasaki M, Wu W, Jiang Y, Yang X, Zhu L, Zhao Z, *Cleary ML.
Targeting Poly(ADP)ribose polymerase in BCR/ABL1-positive cells.
Sci Rep.2023 May 10;13(1):7588. doi: 10.1038/s41598-023-33852-2.
Hiroki H, Ishii Y, Piao J, Namikawa Y, Masutani M, Honda H, Akahane K, Inukai T, Morio T, *Takagi M.
p130Cas is required for androgen-dependent postnatal development regulation
of submandibular glands.
Sci Rep. 2023 Mar 29;13(1):5144. doi: 10.1038/s41598-023-32390-1.
Gao J, Li A, Fujii S, Huang F, Nakatomi C, Nakamura I, Honda H, Kiyoshima T, Eijiro *Jimi E.
Differentiated embryonic chondrocyte expressed gene-1 is a central signaling
component in the development of collagen-induced rheumatoid arthritis.
J Biol Chem. 2023 Mar;299(3):102982. doi: 10.1016/j.jbc.2023.102982.
Wu Y, Wang H, Huo Y, Yan B, Honda H, Liu W, *Yang J
2022
UTX deficiency in neural stem/progenitor cells results in impaired neural
development, fetal ventriculomegaly, and postnatal death.
FASEB J. 2022 Dec;36(12):e22662. doi: 10.1096/fj.202201002RR. Erratum in: FASEB
J. 2023 Feb;37(2):e22771.
Koizumi M, Eto H, Saeki M, Seki M, Fukushima T, Mukai S, Ide H, Sera Y, Iwasaki M, Suzuki Y, Tohei A, *Kishi Y, *Honda H.
In utero transplantation of myoblast and adipose derived mesenchymal stem
cells to murine models of Duchenne muscular dystrophy does not lead to
engraftment and frequently results in fetal death.
Regen Ther. 2022 Oct 20;21:486-493. doi: 10.1016/j.reth.2022.10.003.
Kihara Y, Homma J, Takagi R, Ishigaki K, Yamanouchi K, Honda H , Nagata S, *Yamato M.
A20 (Tnfaip3) expressed in CD4+ T cells suppresses Th2 cell-mediated allergic
airway inflammation in mice .
Biochem Biophys Res Commun. 2022 Nov 12;629:47-53.
Yokoyama Y, Tamachi T, Iwata A, Maezawa Y, Meguro K, Yokota M, Takatori
H, Suto A, Suzuki K, Hirose K, Yamaguchi N, Honda H, *Nakajima H.
Aberrant EVI1 splicing contributes to EVI1-rearranged leukemia.
Blood. 2022 Jun 16:blood.2021015325. doi: 10.1182/blood.2021015325. Epub ahead
of print.
Tanaka A, Nakano TA, Nomura M, Yamazaki H, Bewersdorf JP, Mulet-Lazaro
R, Hogg S, Liu B, Penson A, Yokoyama A, Zang W, Havermans M, Koizumi M, Hayashi Y, Cho H, Kanai A, Lee SC, Xiao M, Koike Y, Zhang Y, Fukumoto
M, Aoyama Y, Konuma T, Kunimoto H, Inaba T, Nakajima H, Honda H, Kawamoto H, Delwel R, *Abdel-Wahab O, *Inoue D.
A novel role of helix-loop-helix transcriptional factor Bhlhe40 in osteoclast
activation.
J Cell Physiol. 2022 Oct;237(10):3912-3926.
Hirata Hirohito, Kamohara A, Murayama M, Nishioka K, Honda H , Urano Y, Soejima H, Oki S, Kukita T, Kawano S, Mawatari M, *Kukita A.
Differentiated embryonic chondrocyte expressed gene-1 (DEC1) enhances the
development of colorectal cancer with an involvement of the STAT3 signaling.
Neoplasia. 2022 May;27:100783. doi: 10.1016/j.neo.2022.100783. Epub 2022 Mar 22.
Shan E, Huo Y, Wang H, Zhang Z, Hu J, Wang G, Liu W, Yan B, Hiroaki H, *Yang J.
Wnt5a plays a critical role in anal opening in mice at an early stage of
embryonic development.
Pediatr Surg Int. 2022 May;38(5):743-747. doi: 10.1007/s00383-022-05103-4. Epub 2022 Feb
25.
Nakata M, Honda H, Iwama A, Terui K, Komatsu S, Shibata R, *Hishiki T.
Deletion of epithelial cell-specific p130Cas impairs the maturation stage
of amelogenesis.
Bone. 2022 Jan;154:116210. doi: 10.1016/j.bone.2021.116210. Epub 2021 Sep 28.
Inoue A, Kiyoshima T, Yoshizaki K, Nakatomi C, Nakatomi M, Ohshima H, Shin
M, Gao J, Tsuru K, Okabe K, Nakamura I, Honda H, Matsuda M, Takahashi I, *Jimi E.
2021
The Loss of H3K27 Histone Demethylase Utx in T Cells Aggravates Allergic
Contact Dermatitis.
J Immunol. 2021 Nov 1;207(9):2223-2234. doi: 10.4049/jimmunol.2001160. Epub 2021
Sep 29.
Inoue T, Omori-Miyake M, Maruyama S, Okabe M, Kuwahara M, Honda H, Miura H, Yamashita M.
Pathological Role of Pin1 in the Development of DSS-Induced Colitis.
Cells. 2021 May 17;10(5):1230. doi: 10.3390/cells10051230.
Matsunaga Y, Hasei S, Yamamotoya T, Honda H, Kushiyama A, Sakoda H, Fujishiro M, Ono H, Ito H, Okabe T, Asano T, Nakatsu
Y.
Progress of genome editing technology and developmental biology useful
for radiation research.
J Radiat Res.2021 May 5;62(Supplement_1):i53-i63. doi: 10.1093/jrr/rraa127.
Miura K, Ogura A, Kobatake K, Honda H, Kaminuma O.
DEC1 deficiency results in accelerated osteopenia through enhanced DKK1
activity and attenuated PI3KCA/Akt/GSK3β signaling.
Metabolism. 2021 May;118:154730. doi: 10.1016/j.metabol.2021.154730.
He S, Guan Y, Wu Y, Zhu L, Yan B, Honda H, Yang J, Liu W.
Mutant ASXL1 induces age-related expansion of phenotypic hematopoietic
stem cells through activation of Akt/mTOR pathway.
Nat Commun. 2021 Mar 23;12(1):1826. doi: 10.1038/s41467-021-22053-y.
Fujino T, Goyama S, Sugiura Y, Inoue D, Asada S, Yamasaki S, Matsumoto A, Yamaguchi K, Isobe Y, Tsuchiya A, Shikata S,
Sato N, Morinaga H, Fukuyama T, Tanaka Y, Fukushima T, Takeda R, Yamamoto
K, Honda H, Nishimura EK, Furukawa Y, Shibata T, Abdel-Wahab O, Suematsu M, Kitamura
T.
UTX maintains the functional integrity of the murine hematopoietic system
by globally regulating aging-associated genes.
Blood. 2021 Feb 18;137(7):908-922. doi: 10.1182/blood.2019001044..
Sera Y, Nakata Y, Ueda T, Yamasaki N, Koide S, Kobayashi H, Ikeda KI, Kobatake
K, Iwasaki M, Oda H, Wolff L, Kanai A, Nagamachi A, Inaba T, Sotomaru Y, Ichinohe T,
Koizumi M, Miyakawa Y, Honda ZI, Iwama A, Suda T, Takubo K, Honda H.
2020
Sufficiency for inducible Caspase-9 safety switch in human pluripotent
stem cells and disease cells.
Gene Ther. 2020 Nov;27(10-11):525-534. doi: 10.1038/s41434-020-0179-z. Epub 2020
Jul 23.
Nishimura T, Xu H, Iwasaki M, Karigane D, Saavedra B, Takahashi Y, Suchy FP, Monobe S, Martin RM, Ohtaka
M, Nakanishi M, Burrows SR, Cleary ML, Majeti R, Shibuya A, Nakauchi H.
Association of aberrant ASNS imprinting with asparaginase sensitivity and
chromosomal abnormality in childhood BCP-ALL.
Blood. 2020 Nov 12;136(20):2319-2333. doi: 10.1182/blood.2019004090.
Watanabe A, Miyake K, Nordlund J, Syvänen AC, van der Weyden L, Honda H, Yamasaki N, Nagamachi A, Inaba T, Ikawa T, Urayama KY, Kiyokawa N, Ohara
A, Kimura S, Kubota Y, Takita J, Goto H, Sakaguchi K, Minegishi M, Iwamoto
S, Shinohara T, Kagami K, Abe M, Akahane K, Goi K, Sugita K, Inukai T.
HHEX promotes myeloid transformation in cooperation with mutant ASXL1.
Blood. 2020 Oct 1;136(14):1670-1684. doi: 10.1182/blood.2019004613.
Takeda R, Asada S, Park SJ, Yokoyama A, Becker HJ, Kanai A, Visconte V,
Hershberger C, Hayashi Y, Yonezawa T, Tamura M, Fukushima T, Tanaka Y,
Fukuyama T, Matsumoto A, Yamasaki S, Nakai K, Yamazaki S, Inaba T, Shibata
T, Inoue D, Honda H, Goyama S, Maciejewski JP, Kitamura T.
Jmjd3 Plays Pivotal Roles in the Proper Development of Early-Born Retinal
Lineages: Amacrine, Horizontal, and Retinal Ganglion Cells.
Invest Ophthalmol Vis Sci. 2020 Sep 1;61(11):43. doi: 10.1167/iovs.61.11.43.
Iwagawa T, Honda H, Watanabe S.
Dual Regulation of Histone Methylation by mTOR Complexes Controls Glioblastoma
Tumor Cell Growth via EZH2 and SAM.
Mol Cancer Res. 2020 Aug;18(8):1142-1152. doi: 10.1158/1541-7786.MCR-20-0024. Epub 2020
May 4.
Harachi M, Masui K, Honda H, Muragaki Y, Kawamata T, Cavenee WK, Mischel PS, Shibata N.
H3K27me3 demethylase UTX regulates the differentiation of a subset of bipolar
cells in the mouse retina.
Genes Cells. 2020 Jun;25(6):402-412. doi: 10.1111/gtc.12767. Epub 2020 Apr 14.
Umutoni D, Iwagawa T, Baba Y, Tsuhako A, Honda H, Aihara M, Watanabe S.
Accumulation of versican facilitates wound healing: Implication of its
initial ADAMTS-cleavage site.
Matrix Biol. 2020 May;87:77-93. doi: 10.1016/j.matbio.2019.10.006. Epub 2019 Oct 26.
Islam S, Chuensirikulchai K, Khummuang S, Keratibumrungpong T, Kongtawelert
P, Kasinrerk W, Hatano S, Nagamachi A, Honda H, Watanabe H.
Kdm6a Deficiency Activates Inflammatory Pathways, Promotes M2 Macrophage
Polarization, and Causes Bladder Cancer in Cooperation with p53 Dysfunction.
Clin Cancer Res. 2020 Apr 15;26(8):2065-2079. doi: 10.1158/1078-0432.CCR-19-2230. Epub
2020 Feb 11.
Kobatake K, Ikeda KI, Nakata Y, Yamasaki N, Ueda T, Kanai A, Sentani K,
Sera Y, Hayashi T, Koizumi M, Miyakawa Y, Inaba T, Sotomaru Y, Kaminuma O, Ichinohe T, Honda ZI, Yasui
W, Horie S, Black PC, Matsubara A, *Honda H.
Kif1c regulates osteoclastic bone resorption as a downstream molecule of
p130Cas.
Cell Biochem Funct. 2020 Apr;38(3):300-308. doi: 10.1002/cbf.3476. Epub 2019 Dec 30.
Kobayakawa M, Matsubara T, Mizokami A, Hiura F, Takakura N, Kokabu S, Matsuda
M, Yasuda H, Nakamura I, Takei Y, Honda H, Hosokawa R, Jimi E.
2019
The loss of dopaminergic neurons in DEC1 deficient mice potentially involves
the decrease of PI3K/Akt/GSK3β signaling.
Aging (Albany NY). 2019 Dec 28;11(24):12733-12753. doi: 10.18632/aging.102599. Epub 2019
Dec 28.
Zhu Z, Yichen W, Ziheng Z, Dinghao G, Ming L, Wei L, Enfang S, Gang H,
Honda H, Jian Y.
Discrimination of Dormant and Active Hematopoietic Stem Cells by G0 Marker
Reveals Dormancy Regulation by Cytoplasmic Calcium.
Cell Rep. 2019 Dec 17;29(12):4144-4158.e7. doi: 10.1016/j.celrep.2019.11.061.
Fukushima T, Tanaka Y, Hamey FK, Chang CH, Oki T, Asada S, Hayashi Y, Fujino T, Yonezawa T, Takeda R, Kawabata KC, Fukuyama T, Umemoto
T, Takubo K, Takizawa H, Goyama S, Ishihama Y, Honda H, Göttgens B, Kitamura T.
High-efficiency CRISPR induction of t(9;11) chromosomal translocations
and acute leukemias in human blood stem cells.
Blood Adv. 2019 Oct 8;3(19):2825-2835. doi: 10.1182/bloodadvances.2019000450.
Jeong J, Jager A, Domizi P, Pavel-Dinu M, Gojenola L, Iwasaki M, Wei MC, Pan F, Zehnder JL, Porteus MH, Davis KL, Cleary ML.
MicroRNA-127-3p controls murine hematopoietic stem cell maintenance by
limiting differentiation.
Haematologica. 2019 Sep;104(9):1744-1755. doi: 10.3324/haematol.2018.198499. Epub 2019
Feb 21.
Crisafulli L, Muggeo S, Uva P, Wang Y, Iwasaki M, Locatelli S, Anselmo A, Colombo FS, Carlo-Stella C, Cleary ML, Villa
A, Gentner B, Ficara F.
Mechanical regulation of bone homeostasis through p130Cas-mediated alleviation
of NF-κB activity.
Sci Adv. 2019 Sep 25;5(9):eaau7802. doi: 10.1126/sciadv.aau7802.
Miyazaki T, Zhao Z, Ichihara Y, Yoshino D, Imamura T, Sawada K, Hayano
S, Kamioka H, Mori S, Hirata H, Araki K, Kawauchi K, Shigemoto K, Tanaka
S, Bonewald LF, Honda H, Shinohara M, Nagao M, Ogata T, Harada I, Sawada Y.
Lysine-specific demethylase 1 accelerates oncogenesis in p53 heterozygous
mice via transcriptional repression of the residual Trp53 allele.
Leuk Res. 2019 Jul;82:29-32. doi: 10.1016/j.leukres.2019.05.008. Epub 2019 May 23.
Wada T, Kikuchi J, Koyama D, Honda H, Furukawa Y.
Loss of Endothelium-Derived Wnt5a Is Associated With Reduced Pericyte Recruitment
and Small Vessel Loss in Pulmonary Arterial Hypertension.
Circulation. 2019 Apr 2;139(14):1710-1724. doi: 10.1161/CIRCULATIONAHA.118.037642.
Yuan K, Shamskhou EA, Orcholski ME, Nathan A, Reddy S, Honda H, Mani V, Zeng Y, Ozen MO, Wang L, Demirci U, Tian W, Nicolls MR, de Jesus
Perez VA.
2018
Paradoxical counteraction by imatinib against cell death in myeloid progenitor
32D cells expressing p210BCR-ABL.
Oncotarget. 2018 Aug 3;9(60):31682-31696. doi: 10.18632/oncotarget.25849.
Takita M, Tsukahara F, Mishima T, Ieguchi K, Yamada M, Honda H, Maru Y.
MLL leukemia induction by t(9;11) chromosomal translocation in human hematopoietic
stem cells using genome editing.
Blood Adv. 2018 Apr 24;2(8):832-845. doi: 10.1182/bloodadvances.2017013748.
Schneidawind C, Jeong J, Schneidawind D, Kim IS, Duque-Afonso J, Wong SHK,
Iwasaki M, Breese EH, Zehnder JL, Porteus M, Cleary ML.
Expression of mutant Asxl1 perturbs hematopoiesis and promotes susceptibility
to leukemic transformation.
J Exp Med. 2018 Jun 4;215(6):1729-1747. doi: 10.1084/jem.20171151. Epub 2018 Apr
11.
Nagase R, Inoue D, Pastore A, Fujino T, Hou HA, Yamasaki N, Goyama S, Saika
M, Kanai A, Sera Y, Horikawa S, Ota Y, Asada S, Hayashi Y, Kawabata KC, Takeda R, Tien HF,
Honda H, Abdel-Wahab O, Kitamura T.
A paralogous pair of mammalian host restriction factors form a critical
host barrier against poxvirus infection.
PLoS Pathog. 2018 Feb 15;14(2):e1006884. doi: 10.1371/journal.ppat.1006884.
Meng X, Zhang F, Yan B, Si C, Honda H, Nagamachi A, Sun LZ, Xiang Y.
2017
Overexpression of Rev1 promotes the development of carcinogen-induced intestinal
adenomas via accumulation of point mutation and suppression of apoptosis
proportionally to the Rev1 expression level.
Carcinogenesis. 2017 May 1;38(5):570-578. doi: 10.1093/carcin/bgw208.
Sasatani M, Xi Y, Kajimura J, Kawamura T, Piao J, Masuda Y, Honda H, Kubo K, Mikamoto T, Watanabe H, Xu Y, Kawai H, Shimura T, Noda A, Hamasaki
K, Kusunoki Y, Zaharieva EK, Kamiya K.
Acquired expression of CblQ367P in mice induces dysplastic myelopoiesis
mimicking chronic myelomonocytic leukemia.
Blood. 2017 Apr 13;129(15):2148-2160. doi: 10.1182/blood-2016-06-724658. Epub
2017 Feb 16.
Nakata Y, Ueda T, Nagamachi A, Yamasaki N, Ikeda KI, Sera Y, Takubo K, Kanai A, Oda H, Sanada M, Ogawa S, Tsuji K, Ebihara Y, Wolff
L, Honda ZI, Suda T, Inaba T, *Honda H.
2016
Propagation of trimethylated H3K27 regulated by polycomb protein EED is
required for embryogenesis, hematopoietic maintenance, and tumor suppression.
Proc Natl Acad Sci U S A. 2016 Sep 13;113(37):10370-5. doi: 10.1073/pnas.1600070113. Epub 2016 Aug
30.
Ueda T, Nakata Y, Nagamachi A, Yamasaki N, Kanai A, Sera Y, Sasaki M, Matsui H, Honda Z, Oda H, Wolff L, Inaba T, *Honda H.
Maintenance of the functional integrity of mouse hematopoiesis by EED and
promotion of leukemogenesis by EED haploinsufficiency.
Sci Rep. 2016 Jul 19;6:29454. doi: 10.1038/srep29454.
Ikeda K, Ueda T, Yamasaki N, Nakata Y, Sera Y, Nagamachi A, Miyama T, Kobayashi H, Takubo K, Kanai A, Oda H, Wolff L,
Honda Z, Ichinohe T, Matsubara A, Suda T, Inaba T, *Honda H.
Identification of cooperative genes for E2A-PBX1 to develop acute lymphoblastic
leukemia.
Cancer Sci. 2016 Jul;107(7):890-8. doi: 10.1111/cas.12945. Epub 2016 Jun 13.
Sera Y, Yamasaki N, Oda H, Nagamachi A, Wolff L, Inukai T, Inaba T, *Honda H.
Transcriptional regulator Bhlhe40 works as a cofactor of T-bet in the regulation
of IFN-γ production in iNKT cells.
Proc Natl Acad Sci U S A. 2016 Jun 14;113(24):E3394-402. doi: 10.1073/pnas.1604178113. Epub 2016
May 25.
Kanda M, Yamanaka H, Kojo S, Usui Y, Honda H, Sotomaru Y, Harada M, Taniguchi M, Suzuki N, Atsumi T, Wada H, Baghdadi
M, Seino K.
The Histone Demethylase FBXL10 Regulates the Proliferation of Spermatogonia
and Ensures Long-Term Sustainable Spermatogenesis in Mice.
Biol Reprod. 2016 Apr;94(4):92. doi: 10.1095/biolreprod.115.135988. Epub 2016 Mar 16.
Ozawa M, Fukuda T, Sakamoto R, Honda H, Yoshida N.
ALK(R1275Q) perturbs extracellular matrix, enhances cell invasion and leads
to the development of neuroblastoma in cooperation with MYCN.
Oncogene. 2016 Aug 25;35(34):4447-58. doi: 10.1038/onc.2015.519. Epub 2016 Feb 1.
Ueda T, Nakata Y, Yamasaki N, Oda H, Sentani K, Kanai A, Onishi N, Ikeda
K, Sera Y, Honda ZI, Tanaka K, Sata M, Ogawa S, Yasui W, Saya H, Takita J, *Honda H.
2015
WNT5a is required for normal ovarian follicle development and antagonizes
gonadotropin responsiveness in granulosa cells by suppressing canonical
WNT signaling.
FASEB J. 2016 Apr;30(4):1534-47. doi: 10.1096/fj.15-280313. Epub 2015 Dec 14.
Abedini A, Zamberlam G, Lapointe E, Tourigny C, Boyer A, Paquet M, Hayashi
K, Honda H, Kikuchi A, Price C, Boerboom D.
Prolyl isomerase Pin1 negatively regulates AMP-activated protein kinase
(AMPK) by associating with the CBS domain in the γ subunit.
J Biol Chem. 2015 Oct 2;290(40):24255-66. doi: 10.1074/jbc.M115.658559. Epub 2015 Aug
14.
Nakatsu Y, Iwashita M, Sakoda H, Ono H, Nagata K, Matsunaga Y, Fukushima
T, Fujishiro M, Kushiyama A, Kamata H, Takahashi S, Katagiri H, Honda H, Kiyonari H, Uchida T, Asano T.
Fbxl10 overexpression in murine hematopoietic stem cells induces leukemia
involving metabolic activation and upregulation of Nsg2.
Blood. 2015 May 28;125(22):3437-46. doi: 10.1182/blood-2014-03-562694. Epub 2015
Apr 14.
Ueda T, Nagamachi A, Takubo K, Yamasaki N, Matsui H, Kanai A, Nakata Y,
Ikeda K, Konuma T, Oda H, Wolff L, Honda Z, Wu X, Helin K, Iwama A, Suda
T, Inaba T, *Honda H.
Overexpression of the shortest isoform of histone demethylase LSD1 primes
hematopoietic stem cells for malignant transformation.
Blood. 2015 Jun 11;125(24):3731-46. doi: 10.1182/blood-2014-11-610907. Epub 2015
Apr 22.
Wada T, Koyama D, Kikuchi J, Honda H, Furukawa Y.
The Wnt5a-Ror2 axis promotes the signaling circuit between interleukin-12
and interferon-γ in colitis.
Sci Rep. 2015 Jun 1;5:10536. doi: 10.1038/srep10536.
Sato A, Kayama H, Shojima K, Matsumoto S, Koyama H, Minami Y, Nojima S,
Morii E, Honda H, Takeda K, Kikuchi A.
2014
Evi1 defines leukemia-initiating capacity and tyrosine kinase inhibitor
resistance in chronic myeloid leukemia.
Oncogene. 2014 Oct 16;33(42):5028-38. doi: 10.1038/onc.2014.108. Epub 2014 Apr 21.
Sato T, Goyama S, Kataoka K, Nasu R, Tsuruta-Kishino T, Kagoya Y, Nukina
A, Kumagai K, Kubota N, Nakagawa M, Arai S, Yoshimi A, Honda H, Kadowaki T, Kurokawa M.
The IL-2/CD25 axis maintains distinct subsets of chronic myeloid leukemia-initiating
cells.
Blood. 2014 Apr 17;123(16):2540-9. doi: 10.1182/blood-2013-07-517847. Epub 2014
Feb 26.
Kobayashi CI, Takubo K, Kobayashi H, Nakamura-Ishizu A, Honda H, Kataoka K, Kumano K, Akiyama H, Sudo T, Kurokawa M, Suda T.
Acquired deficiency of A20 results in rapid apoptosis, systemic inflammation,
and abnormal hematopoietic stem cell function.
PLoS One. 2014 Jan 31;9(1):e87425. doi: 10.1371/journal.pone.0087425.
Nagamachi A, Nakata Y, Ueda T, Yamasaki N, Ebihara Y, Tsuji K, Honda Z,
Takubo K, Suda T, Oda H, Inaba T, *Honda H.
2013
Haploinsufficiency of SAMD9L, an endosome fusion facilitator, causes myeloid
malignancies in mice mimicking human diseases with monosomy 7.
Cancer Cell. 2013 Sep 9;24(3):305-17. doi: 10.1016/j.ccr.2013.08.011.
Nagamachi A, Matsui H, Asou H, Ozaki Y, Aki D, Kanai A, Takubo K, Suda
T, Nakamura T, Wolff L, *Honda H, *Inaba T.
ATM-dependent DNA damage-response pathway as a determinant in chronic myelogenous
leukemia.
DNA Repair (Amst). 2013 Jul;12(7):500-7. doi: 10.1016/j.dnarep.2013.04.022. Epub 2013 May
19.
Takagi M, Sato M, Piao J, Miyamoto S, Isoda T, Kitagawa M, Honda H, Mizutani S.
CIZ1, a p21Cip1/Waf1-interacting protein, functions as a tumor suppressor
in vivo.
FEBS Lett. 2013 May 21;587(10):1529-35. doi: 10.1016/j.febslet.2013.03.034. Epub
2013 Apr 11.
Nishibe R, Watanabe W, Ueda T, Yamasaki N, Koller R, Wolff L, Honda Z,
Ohtsubo M, *Honda H.
p130Cas, Crk-associated substrate, plays important roles in osteoclastic
bone resorption.
J Bone Miner Res. 2013 Dec;28(12):2449-62. doi: 10.1002/jbmr.1936.
Nagai Y, Osawa K, Fukushima H, Tamura Y, Aoki K, Ohya K, Yasuda H, Hikiji
H, Takahashi M, Seta Y, Seo S, Kurokawa M, Kato S, Honda H, Nakamura I, Maki K, Jimi E.
Skeletal muscle adaptation in response to mechanical stress in p130cas-/-
mice.
Am J Physiol Cell Physiol. 2013 Mar;304(6):C541-7. doi: 10.1152/ajpcell.00243.2012. Epub 2013 Jan
16.
Akimoto T, Okuhira K, Aizawa K, Wada S, Honda H, Fukubayashi T, Ushida T.
Induction of pluripotent stem cells from primordial germ cells by single
reprogramming factors.
Stem Cells. 2013 Mar;31(3):479-87. doi: 10.1002/stem.1303.
Nagamatsu G, Kosaka T, Saito S, Honda H, Takubo K, Kinoshita T, Akiyama H, Sudo T, Horimoto K, Oya M, Suda T.
I
2012
Poly-ADP ribosylation of Miki by tankyrase-1 promotes centrosome maturation.
Mol Cell. 2012 Sep 14;47(5):694-706. doi: 10.1016/j.molcel.2012.06.033. Epub 2012
Aug 2.
Ozaki Y, Matsui H, Asou H, Nagamachi A, Aki D, Honda H, Yasunaga S, Takihara Y, Yamamoto T, Izumi S, Ohsugi M, Inaba T.
EED mutants impair polycomb repressive complex 2 in myelodysplastic syndrome
and related neoplasms.
Leukemia. 2012 Dec;26(12):2557-60. doi: 10.1038/leu.2012.146. Epub 2012 Jun 1.
Ueda T, Sanada M, Matsui H, Yamasaki N, Honda ZI, Shih LY, Mori H, Inaba
T, Ogawa S, *Honda H.
Mouse Samd9l is not a functional paralogue of the human SAMD9, the gene
mutated in normophosphataemic familial tumoral calcinosis.
Exp Dermatol. 2012 Jul;21(7):554-6. doi: 10.1111/j.1600-0625.2012.01524.x.
Li Q, Guo H, Matsui H, Honda H, Inaba T, Sundberg JP, Sprecher E, Uitto J.
Oncogenic fusion E2A-HLF sensitizes t(17;19)-positive acute lymphoblastic
leukemia to TRAIL-mediated apoptosis by upregulating the expression of
death receptors.
Leukemia. 2012 Dec;26(12):2483-93. doi: 10.1038/leu.2012.139. Epub 2012 May 30.
Zhang X, Inukai T, Hirose K, Akahane K, Kuroda I, Honna-Oshiro H, Kagami
K, Goi K, Nakamura K, Kobayashi M, Endo M, Yagita H, Kurosawa H, Thomas
Look A, Honda H, Inaba T, Nakazawa S, Sugita K.
Ink4a and Arf are crucial factors in the determination of the cell of origin
and the therapeutic sensitivity of Myc-induced mouse lymphoid tumor.
Oncogene. 2012 Jun 7;31(23):2849-61. doi: 10.1038/onc.2011.462. Epub 2011 Oct 10.
Sugihara E, Shimizu T, Kojima K, Onishi N, Kai K, Ishizawa J, Nagata K,
Hashimoto N, Honda H, Kanno M, Miwa M, Okada S, Andreeff M, Saya H.
2011
Crk-associated substrate lymphocyte type regulates myeloid cell motility
and suppresses the progression of leukemia induced by p210Bcr/Abl.
Cancer Sci. 2011 Dec;102(12):2109-17. doi: 10.1111/j.1349-7006.2011.02066.x. Epub
2011 Sep 23.
Seo S, Nakamoto T, Takeshita M, Lu J, Sato T, Suzuki T, Kamikubo Y, Ichikawa
M, Noda M, Ogawa S, Honda H, Oda H, Kurokawa M.
The Samd9L gene: transcriptional regulation and tissue-specific expression
in mouse development.
J Invest Dermatol. 2011 Jul;131(7):1428-34. doi: 10.1038/jid.2011.61. Epub 2011 Mar 17.
Jiang Q, Quaynor B, Sun A, Li Q, Matsui H, Honda H, Inaba T, Sprecher E, Uitto J.
Hemp, an mbt domain-containing protein, plays essential roles in hematopoietic
stem cell function and skeletal formation.
Proc Natl Acad Sci U S A. 2011 Feb 8;108(6):2468-73. doi: 10.1073/pnas.1003403108. Epub 2011 Jan
20.
*Honda H, Takubo K, Oda H, Kosaki K, Tazaki T, Yamasaki N, Miyazaki K, Moore KA,
Honda Z, Suda T, Lemischka IR.
2010 以前
2010
The role of the basic helix-loop-helix transcription factor Dec1 in the
regulatory T cells.
J Immunol. 2010 Dec 15;185(12):7330-9. doi: 10.4049/jimmunol.1001381. Epub 2010 Nov
5.
Miyazaki K, Miyazaki M, Guo Y, Yamasaki N, Kanno M, Honda Z, Oda H, Kawamoto
H, *Honda H.
A 5' untranslated region containing the IRES element in the Runx1 gene
is required for angiogenesis, hematopoiesis and leukemogenesis in a knock-in
mouse model.
Dev Biol. 2010 Sep 15;345(2):226-36. doi: 10.1016/j.ydbio.2010.07.015. Epub 2010
Jul 18.
Nagamachi A, Htun PW, Ma F, Miyazaki K, Yamasaki N, Kanno M, Inaba T, Honda
Z, Okuda T, Oda H, Tsuji K, *Honda H.
p130Cas, Crk-associated substrate plays essential roles in liver development
by regulating sinusoidal endothelial cell fenestration.
Hepatology. 2010 Sep;52(3):1089-99. doi: 10.1002/hep.23767.
Tazaki T, Sasaki T, Uto K, Yamasaki N, Tashiro S, Sakai R, Tanaka M, Oda
H, Honda Z, *Honda H.
Identification of Zfp521/ZNF521 as a cooperative gene for E2A-HLF to develop
acute B-lineage leukemia.
Oncogene. 2010 Apr 1;29(13):1963-75. doi: 10.1038/onc.2009.475. Epub 2010 Jan 11.
Yamasaki N, Miyazaki K, Nagamachi A, Koller R, Oda H, Miyazaki M, Sasaki
T, Honda ZI, Wolff L, Inaba T, *Honda H.
2009
Identification of CENP-V as a novel microtubule-associating molecule that
activates Src family kinases through SH3 domain interaction.
Genes Cells. 2009 Dec;14(12):1383-94. doi: 10.1111/j.1365-2443.2009.01355.x. Epub 2009
Nov 20.
Honda Z, Suzuki T, *Honda H.
Gain-of-function of mutated C-CBL tumour suppressor in myeloid neoplasms.
Nature. 2009 Aug 13;460(7257):904-8. doi: 10.1038/nature08240. Epub 2009 Jul 20.
Sanada M, Suzuki T, Shih LY, Otsu M, Kato M, Yamazaki S, Tamura A, Honda H, Sakata-Yanagimoto M, Kumano K, Oda H, Yamagata T, Takita J, Gotoh N,
Nakazaki K, Kawamata N, Onodera M, Nobuyoshi M, Hayashi Y, Harada H, Kurokawa
M, Chiba S, Mori H, Ozawa K, Omine M, Hirai H, Nakauchi H, Koeffler HP,
Ogawa S.
Haploinsufficiency and acquired loss of Bcl11b and H2AX induces blast crisis
of chronic myelogenous leukemia in a transgenic mouse model.
Cancer Sci. 2009 Jul;100(7):1219-26. doi: 10.1111/j.1349-7006.2009.01172.x. Epub 2009
Apr 21.
Nagamachi A, Yamasaki N, Miyazaki K, Oda H, Miyazaki M, Honda Z, Kominami
R, Inaba T, *Honda H.
Enhanced expression of p210BCR/ABL and aberrant expression of Zfp423/ZNF423
induce blast crisis of chronic myelogenous leukemia.
Blood. 2009 May 7;113(19):4702-10. doi: 10.1182/blood-2007-05-088724. Epub 2009
Feb 20.
Miyazaki K, Yamasaki N, Oda H, Kuwata T, Kanno Y, Miyazaki M, Komeno Y,
Kitaura J, Honda Z, Warming S, Jenkins NA, Copeland NG, Kitamura T, Nakamura
T, *Honda H.
Elevated intraocular pressure, optic nerve atrophy, and impaired retinal
development in ODAG transgenic mice.
Invest Ophthalmol Vis Sci. 2009 Jan;50(1):242-8. doi: 10.1167/iovs.08-2206. Epub 2008 Sep 12.
Sasaki T, Watanabe W, Muranishi Y, Kanamoto T, Aihara M, Miyazaki K, Tamura
H, Saeki T, Oda H, Souchelnytskyi N, Souchelnytskyi S, Aoyama H, Honda
Z, Furukawa T, Mishima HK, Kiuchi Y, *Honda H.
2008
Thymocyte proliferation induced by pre-T cell receptor signaling is maintained
through polycomb gene product Bmi-1-mediated Cdkn2a repression.
Immunity. 2008 Feb;28(2):231-45. doi: 10.1016/j.immuni.2007.12.013.
Miyazaki M, Miyazaki K, Itoi M, Katoh Y, Guo Y, Kanno R, Katoh-Fukui Y,
Honda H, Amagai T, van Lohuizen M, Kawamoto H, Kanno M.
Functional analysis of Src homology 3-encoding exon (exon 2) of p130Cas
in primary fibroblasts derived from exon 2-specific knockout mice.
Genes Cells. 2008 Feb;13(2):145-57. doi: 10.1111/j.1365-2443.2007.01156.x.
Tazaki T, Miyazaki K, Hiyama E, Nakamoto T, Sakai R, Yamasaki N, Honda
Z, Noda M, Miyasaka N, Sueda T, *Honda H.
Overexpression/enhanced kinase activity of BCR/ABL and altered expression
of Notch1 induced acute leukemia in p210BCR/ABL transgenic mice.
Oncogene. 2008 May 29;27(24):3465-74. doi: 10.1038/sj.onc.1211007. Epub 2008 Jan
14.
Mizuno T, Yamasaki N, Miyazaki K, Tazaki T, Koller R, Oda H, Honda ZI,
Ochi M, Wolff L, *Honda H.
2007
Role of osteoprotegerin in arterial calcification: development of new animal
model.
Arterioscler Thromb Vasc Biol. 2007 Sep;27(9):2058-64. doi: 10.1161/ATVBAHA.107.147868. Epub 2007 Jul
5.
Orita Y, Yamamoto H, Kohno N, Sugihara M, Honda H, Kawamata S, Mito S, Soe NN, Yoshizumi M.
2005
FcgammaRIIB Ile232Thr transmembrane polymorphism associated with human
systemic lupus erythematosus decreases affinity to lipid rafts and attenuates
inhibitory effects on B cell receptor signaling.
Hum Mol Genet. 2005 Oct 1;14(19):2881-92. doi: 10.1093/hmg/ddi320. Epub 2005 Aug 22.
Kono H, Kyogoku C, Suzuki T, Tsuchiya N, Honda H, Yamamoto K, Tokunaga K, Honda Z.
2004
Role of Dok-1 and Dok-2 in leukemia suppression.
J Exp Med. 2004 Dec 20;200(12):1689-95. doi: 10.1084/jem.20041306.
Niki M, Di Cristofano A, Zhao M, Honda H, Hirai H, Van Aelst L, Cordon-Cardo C, Pandolfi PP.
Roles of Bim in apoptosis of normal and Bcr-Abl-expressing hematopoietic
progenitors.
Mol Cell Biol. 2004 Jul;24(14):6172-83. doi: 10.1128/MCB.24.14.6172-6183.2004.
Kuribara R, Honda H, Matsui H, Shinjyo T, Inukai T, Sugita K, Nakazawa S, Hirai H, Ozawa K,
Inaba T.
2003
Myeloproliferative disease in transgenic mice expressing P230 Bcr/Abl:
longer disease latency, thrombocytosis, and mild leukocytosis.
Blood. 2003 Jul 1;102(1):320-3. doi: 10.1182/blood-2002-10-3182. Epub 2003 Mar
6.
Inokuchi K, Dan K, Takatori M, Takahuji H, Uchida N, Inami M, Miyake K,
Honda H, Hirai H, Shimada T.
2002
Identification of functional hypoxia response elements in the promoter
region of the DEC1 and DEC2 genes.
J Biol Chem. 2002 Dec 6;277(49):47014-21. doi: 10.1074/jbc.M204938200. Epub 2002 Sep
26.
Miyazaki K, Kawamoto T, Tanimoto K, Nishiyama M, Honda H, Kato Y.
Differential regulation of cell migration, actin stress fiber organization,
and cell transformation by functional domains of Crk-associated substrate.
J Biol Chem. 2002 Jul 26;277(30):27265-72. doi: 10.1074/jbc.M203063200. Epub 2002 May
14.
Huang J, Hamasaki H, Nakamoto T, Honda H, Hirai H, Saito M, Takato T, Sakai R.
Analysis of gene expression profile in p130(Cas)-deficient fibroblasts.
Biochem Biophys Res Commun. 2002 Jun 14;294(3):635-41. doi: 10.1016/S0006-291X(02)00527-2.
Nakamoto T, Suzuki T, Huang J, Matsumura T, Seo S, Honda H, Sakai R, Hirai H.
Members of the Zyxin family of LIM proteins interact with members of the
p130Cas family of signal transducers.
J Biol Chem. 2002 Mar 15;277(11):9580-9. doi: 10.1074/jbc.M106922200. Epub 2002 Jan
8.
Yi J, Kloeker S, Jensen CC, Bockholt S, Honda H, Hirai H, Beckerle MC.
英文総説
2022
The unique function of p130Cas in regulating the bone metabolism.
Pharmacol Ther. 2022 Feb;230:107965. doi: 10.1016/j.pharmthera.2021.107965. Epub 2021
Aug 12.
Jimi E, Honda H, Nakamura I.
2018
The enigma of monosomy 7.
Blood. 2018 Jun 28;131(26):2891-2898. doi: 10.1182/blood-2017-12-822262. Epub
2018 Apr 3.
Inaba T, Honda H, Matsui H.
2015
-7/7q- syndrome in myeloid-lineage hematopoietic malignancies: attempts
to understand this complex disease entity.
Oncogene. 2015 May 7;34(19):2413-25. doi: 10.1038/onc.2014.196. Epub 2014 Jul 7.
Honda H, Nagamachi A, Inaba T.
2014
A long lasting puzzle for -7/7q- syndrome.
Oncotarget. 2014 Jan 15;5(1):7-8. doi: 10.18632/oncotarget.1763.
Honda H, Inaba T.
2013
Hematopoietic Stem Cell Function and Skeletal Formation: Positive Role
of Hemp Gene
Stem Cells and Cancer Stem Cells Volume 9 (Therapeutic Applications in Disease and Injury, Part IV, Hematopoietic
Stem Cells),p155～p162, Springer 2013
Honda H
和文総説
2019
世良康如, 本田浩章 疾患モデルマウスによるCML急性転化の分子機構の解析
血液内科, 79(6)：688-696, 2019
2013
本田浩章 がんモデルマウス・ラットライブラリ 第10回 白血病モデル2（遺伝子改変モデル）
細胞工学 32 (5), p600-607, 2013
2012
本田浩章 疾患モデルの作製と利用「がん」 第4節 遺伝子改変モデル 第1項「BCR/ABL」
seriesモデル動物利用マニュアル, p466-479, 2012
2009
本田浩章「マウスモデルにレトロウイルスを用いた慢性骨髄性白血病急性転化機構の解析」
血液・腫瘍科、59(6)：700-707、2009
本田浩章 「mini review：p210BCR/ABL トランスジェニックマウス」
今日の移植 22（3） p311-318、2009
2007
本田浩章 「疾患モデルを用いた腫瘍発症の分子機構、造血器腫瘍（基礎・臨床領域における最新の研究動向」
日本臨床増刊号（日本臨床社）p24-33、2007
本田浩章 「染色体転座の分子機構」
細胞 39（9）p385-38、2007
2006
本田浩章 「後天性に誘導可能に目的遺伝子を発現する白血病モデルマウスの作製」
放射線生物研究 41（3）p255-263、2006
2005
本田浩章「白血病モデル動物とその意義、血液疾患 ver.3-State or Arts」
別冊・医学のあゆみ（医歯薬出版株式会社） p191-196、2005
2004
本田浩章 「原爆放射線と慢性骨髄白血病、第44回原子爆弾後障害研究会・特別講演」
広島医学 57（4）、p299-304、 2004
2003
本田浩章、平井久丸 「造血器腫瘍」
モデル動物の作製と維持（エル・アイ・シー出版） p843-857、 2003
本田浩章 「白血病とリンパ腫：ヒト白血病モデル-発生工学が教えること」
Medical Practice（文光堂） 20（7） 、 p1195-1198、 2003
本田浩章 「特集・慢性骨髄性白血病（CML）の基礎と臨床：CMLの動物モデル」
血液・腫瘍科（科学評論社） 46（3）、 p213-221、 2003
2002
本田浩章、平井久丸 「白血病・悪性リンパ腫モデルマウス、免疫疾患 ver.2- State or Arts」
別冊・医学のあゆみ （医歯薬出版株式会社） p324-330、 2002