Tokyo Women's Medical University

Graduate School of Medical Science

Endocrinology

About us

Our clinical and research targets are all endocrinological diseases. Our aim is to groom a medical doctor as a physician scientist who perform clinical and basic research to give the patients the best medical treatment which we think of. Based on our case analysis, clinical and nuclear receptor research (ref.1-7), we would like to solve the critical clinical issues about endocrinological diseases (especially pituitary and adrenal diseases). We look forward to joining you to our department.

Case analysis
　1. Fujita Y, Otsuki M et al.: Exenatide alters absorption of hydrocortisone in a diabetic patient with
　　 panhypopituitarism: Iatrogenic adrenal insufficiency. Diabetes Care. 2013;36(1):e8. doi: 　
　　10.2337/dc12-1499
Proposal for new disease concept
a. SITSH after surgery for Cushing's syndrome
　2. Tamada D, Otsuki M et al.: Hyperthyroidism due to thyroid stimulating hormone secretion after
　　surgery for Cushing's syndrome: A novel cause of the syndrome of inappropriate secretion of
　　thyroid stimulating hormone. J Clin Endocrinol Metab. 2013 Jul;98(7):2656-62.
b. Primary aldosteronism with normal plasma aldosterone
　3. Murata M, Otsuki M et al.: Plasma aldosterone level within the normal range is less associated
　　with cardio- and cerebrovascular risk in primary aldosteronism. J Hypertens. 2017
　　 May;35(5):1079-1085.
Novel diagnostic method and novel significance of endocrine function test
　4. Tamada D, Otsuki M et al.: TSH ratio as a novel diagnostic method for Cushing's syndrome.
　　Endocr J. 2018 Aug 27;65(8):841-848.
　5. Mukai K, Otsuki M et al.: Clinical characteristics of acromegalic patients with paradoxical growth
　　 hormone response to oral glucose load. J Clin Endocrinol Metab. 2019 May 1;104(5):1637-1644.
Novel evidence by multi-institutional, cross-sectional study
　6. Saiki A, Otsuki M et al.: Diabetes mellitus itself increases cardio-cerebrovascular risk and renal
　　 complications in primary aldosteronism. J Clin Endocrinol Metab. 2020 Jul 1;105(7):dgaa177. doi:
　　 10.1210/clinem/dgaa177.
Nuclear receptor biology
　7. Hayashi R, Otsuki M et al.: Adipocyte GR Inhibits Healthy Adipose Expansion Through Multiple
　　 Mechanisms in Cushing Syndrome. Endocrinology. 2019 Mar 1;160(3):504-521.

Research

1. to investigate the novel clinical parameter to perform the adequate glucocorticoid replacement in
　 secondary adrenal insufficiency
2. to clarify the significance of glucocorticoid induced adiponectin production by adipocyte
　 glucocorticoid receptor in secondary adrenal insufficiency with sick day
3. to investigate the regulatory mechanism for endocrine abnormality in Cushing’s syndrome
4. to develop the novel diagnostic parameter for primary aldosteronism and Cushing’s syndrome
5. to investigate the real situation of adult 21-hydroxylase deficiency in Japan (Research Committee
　 on Disorders of Adrenal Hormones from the Ministry of Health, Labour and Welfare)

Faculty

Michio Otsuki (Professor and Chair)

Related links

Research Achievements Database

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