Tokyo Women's Medical University

School of Medicine

Department of Transfusion Medicine and Cell Processing

Overview

Our Department of Transfusion Medicine and Cell Processing consists of three full-time physicians and one part-time physician. As a member of Transfusion Medicine and Cell Processing Department, a medical support section, we are responsible for the centralized management and supply of all biologically derived products (blood transfusion) and preparation and supply of cell preparations (cell processing) in the hospital. We also have two laboratories and a sterile cell processing center (CPC) and are actively engaged in research and education. In our research on congenital hemolytic anemia, pure red cell aplasia, and bone marrow failure, specimens are collected from medical institutions nationwide for genetic diagnosis and the search for and identification of novel etiologic genes.　In addition, we also analyze drug-sensitive genes and search for and identify novel pathogenic genes based on genome analysis with the aim of personalized medicine for cancer patients. In immuno-cell therapy research, our department is equipped with cell culture equipment and flow cytometers to develop novel cancer immunotherapies and search for biomarkers. Our department is equipped with a regenerative medicine compliant CPC, and in collaboration with other departments, conducts clinical research on cancer immuno-cell therapy, advanced medicine, and immune tolerance induction therapy in transplantation medicine. We are characterized by its ability to conduct research and clinical application of a wide range of gene diagnosis, gene therapy, and cell therapy/regenerative medicine in a setting close to clinical practice, transfusion-related. In education, we offer a curriculum that allows students to learn a wide range of topics from basic transfusion medicine and testing to cell therapy through cell culture as an elective training.

Education Details

(Undergraduate education and training)
Segment 7
Segment 8
Segment 9

(Post-graduate education)
Orientation for trainees in medical training
Orientation for post-graduate clinical training center
Blood transfusion workshop for nurses

(Training for extramural personnel)
Japanese Society of Blood Transfusion and Cell Therapy Certified Technician System, Designated Institution Training
Certified Nurse Education Center, Surgical Field
Training at facilities designated by the Japanese Society of Blood Transfusion and Cell Therapy (JSBTCT) for the Blood Transfusion Nurse System
Training at facilities affiliated with the Japanese Society of Blood Transfusion and Cell Therapy's Cell Culture Manager Certification System (tentative)

Research Details

Identification of novel biomarkers for Diamond-Blackfan anemia
Development of gene therapy using mouse models of pyruvate kinase deficiency
Development of innovative therapeutic agents for congenital hemolytic anemia and bone marrow failure utilizing iPS cells
Identification of novel etiologic genes for congenital hemolytic anemia
Identification of genomic biomarkers for predicting sensitivity to anticancer drugs and risk of adverse drug reactions useful for personalized cancer care
Establishment of a genomic medical care system using pharmacogenomics and cancer genome analysis
Development and clinical trials of combined cancer immunotherapy
Elucidation of the mechanism of immune exhaustion in advanced cancer patients and development of novel immunotherapy by removing the exhaustion

Faculty

Hitoshi Kanno
Hirohito Kobayashi
Taiju Utsugisawa
Keiko Shimojima Yamamoto

Related links

Research Achievements Database

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