大学院生 滝澤悠己 先生（再生医工学分野・東京慈恵会医科大学）の論文です。
“Effect of basic fibroblast growth factor with collagen/gelatin fixture in a rabbit model of nasal septum perforation”
TAKIZAWA Yuki†*, MORINO Tsunetaro*, TAKAGI Ryo*, OTORI Nobuyoshi*, KOJIMA Hiromi*, YAMATO Masayuki*
Regenerative Therapy, 25:387-394(2024)
doi：10.1016/j.reth.2024.02.001
Abstract
Introduction
The treatment of nasal septum perforation solely by surgical intervention presents significant challenges. This study evaluated the effect of basic fibroblast growth factor (bFGF) in combination with collagen/gelatin on wound healing of nasal septum perforation in a rabbit animal model.
Methods
A nasal septum perforation rabbit model was created. bFGF was added to a collagen/gelatin fixture and placed adjacent to the perforation, which is a complete defect. The rabbits were divided into three groups: the sham group that underwent the surgical procedure only, bFGF (−) group that received collagen/gelatin fixture without bFGF, and bFGF(+) group that received collagen/gelatin fixture with bFGF. The dimensions of the perforations were measured after 4 weeks, and the septum was subjected to histological examination.
Results
All perforations remained open in the sham group (closure rate: 20.4%–83.1%). The closure rates of the bFGF(−) and bFGF(+) groups were 49.4%–68.8% and 72.7%–100%, respectively. No significant difference was noted in the closure rates between the sham and bFGF(−) groups; however, significant differences were observed between the sham and bFGF(+) groups, and the bFGF(−) and bFGF(+) groups (p < 0.05), indicating that bFGF promoted perforation closure.
Conclusions
The study demonstrated that bFGF with collagen/gelatin carrier promoted wound healing in a rabbit model of nasal septum perforation.
